![]() ![]() ![]() She was described by staff as having a "sunny disposition" and had no history of depression, aggression, anxiety, or psychosis. She was employed as a cleaner for a nearby hotel and was well liked by other residents, group home staff, and her employer. The patient had been a group home resident for 15 years, having done well thereīehaviorally over the course of this time. She was on a stable dose of phenytoin for seizure prophylaxis. Ms A is an adult female with Down syndrome, insulin dependent diabetes mellitus, and a history of grand mal seizures that occurred during periods of severe Each patient had a significant improvement in OCD symptoms and did not experience extra-pyramidal symptoms (EPS) or tardive In this article, we report a case series of four adult patients with Down syndrome with co-morbid behaviors consistent with OCD who were treated with SSRIs alone or ( Raitasuo et al., 1998) reported a case of a patient with Down syndrome with anorexia nervosa, major depression, and OCD who had reduction in OCD symptoms with citalopram 40 mg. Of clomipramine 150 mg and fluoxetine 40 mg. Specific to Down syndrome, O'Dwyer ( O'Dwyer, 1992) reported two cases of OCD in patients with Down syndrome, one of whom had a partial response to fluvoxamine 200 mg, and another patient who failed successive trials SSRIs have been reported to be effective treatments of OCD in developmentally Little is known about the pharmacologic management of OCD in patients with Down syndrome. When SSRIs alone do not substantially reduce symptoms, neuroleptics have been shown to be effective 'add-on' therapies in treatment refractory OCD patients ( McDougle et al., 2000). Serotonin Specific Reuptake Inhibitors (SSRIs) have been the mainstays of pharmacologic treatment of OCD in non-developmentally disordered patients ( Greist et al., 1995). Obsessional slowness has been described in patients with Down syndrome ( Charlot et al., 2002), and it has been postulated that compulsive behaviors may be a part of the behavioral presentations of some patients with Down syndrome ( Evans and Gray, 2000). Prevalence estimates for Obsessive Compulsive Disorder (OCD) within the Down syndrome population vary from 0.8 % ( Myers and Pueschel, 1991) to 4.5% ( Prasher, 1995) with ordering and tidiness being the most commonly presenting behaviors ( Prasher and Day, 1995). doi:10.3104/case-studies.299ĭown syndrome is a commonly occurring chromosomal disorder that is associated with psychiatric co-morbidity in 28.9% of cases ( Prasher, 1995). (2006) Obsessive Compulsive Disorder treatment in patients with Down syndrome: A case series.ĭown Syndrome Research and Practice, 10(1), 1-3. This small case series supports the use of these medications in the treatment of co-morbid obsessive compulsive disorder in None of the patientsĮxperienced significant side effects. Substantial reduction in compulsive behaviors with pharmacotherapy of an SSRI alone or with the addition of risperidone to SSRI therapy. In this case series we report four cases of patients with Down syndrome with symptoms consistent with obsessive compulsive disorder. Obsessive Compulsive Disorder treatment in patients with Down syndrome: A case series ![]()
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